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See full prescribing & safety info. Kisqali (ribociclib) is used to treat a certain type of advanced metastatic breast cancer Includes kisqali side effects, interactions and indications. How well does kisqali work for breast cancer See full prescribing & safety information. Kisqali is often used in combination with other therapies, including aromatase inhibitors, to increase its effectiveness It works by targeting and blocking the cell cycle, stopping cancer cells from. Cdks are enzymes involved in cell cycle regulation Novartis recognized kisqali’s potential as a cancer therapy and began clinical trials in breast cancer patients in 2013