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The systemic concentrations of r and s enantiomers, as well as overall bioavailability, are dependent upon the route of administration and the rate and extent of release from the dosage. Verapamil is mainly metabolised by cleavage of the dimethoxyphenylethyl mioety to products with apparently much lower cardiovascular activity than verapamil and demethylation to norverapamil, a m When administered through oral route, it is absorbed completely The route of administration that has 100% bioavailability is the intravenous (iv) route When a drug is administered intravenously, it directly enters the bloodstream, bypassing any barriers that could reduce its availability 3. Because of rapid biotransformation of verapamil during its first pass through the portal circulation, bioavailability ranges from 20% to 35%. Because of rapid biotransformation of verapamil during its first pass through the portal circulation, bioavailability ranges from 20% to 35% Peak plasma concentrations are reached between 1 and 2 hours after oral administration.Corolla Hybrid-only Japan Complete Media Collection #711
