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Toxic granulation is a reactive change in neutrophils, typically occurring in response to significant inflammation or infection The most common cause is severe bacterial infection,. Toxic granulation is often found in patients with bacterial infection and sepsis, [1][2] although the finding is nonspecific [3] patients being treated with chemotherapy [3] or granulocyte colony. The primary cause of toxic granulation is bacterial infections, which trigger the release of granules in neutrophils to fight off bacteria Toxic granulation is defined as the presence of larger, darkly staining granules in the cytoplasm of neutrophils, indicating possible underlying infections, particularly bacterial, or other conditions of. Toxic granulation refers to changes in granulocyte cells seen on examination of the peripheral blood film of patients with inflammatory conditions 1 Toxic granulation are commonly found in patients. Toxic granulation is the presence of large purple or dark blue cytoplasmic granules (primary granules) in neutrophils, bands, and metamyelocytes The granules are slightly larger, more. Toxic granulation is a condition characterized by the presence of abnormal, enlarged, and distorted granules within neutrophils on microscopic examination of blood smears. Hypergranulation, or toxic granulation, is an increase in the number of granules in the neutrophil granulocyte Often the granules are dark purple in color This increase is seen in the case of. In order to report toxic changes, typically two out of the three features should be seen in the majority of neutrophils Toxic granulation is the accumulation of big, dark granules in segmented neutrophils (or, sometimes, in earlier neutrophil precursors) It is likely due to the demand placed on the marrow.