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Steroids are increasingly being used to treat a wide spectrum of otolaryngological disorders Because of the inflammatory mechanisms of most chronic upper airway diseases such as rhinitis and chronic rhinosinusitis, systemic steroids have been used for their treatment for decades. Evidence on the effectiveness of scs varies widely across otolaryngology disorders Apart from a very small number of life threatening ear, nose and throat conditions, steroids are usually not life saving They can be very effective in treating disease and. Another precise clinical indication for steroids is in. Evidence from clinical practice guidelines, systematic reviews, and original research studies supports perioperative systemic corticosteroid use for specific otolaryngologic indications. It is important for ear?nose?throat surgeons to understand the short? and long?term complications associated with steroid use The aim of this study was to review the role of. Corticosteroids readily diffuse into cells and bind to receptor proteins, forming complexes that reduce inflammation by decreasing cytokine production and cellular responses Although the epos and international guidelines for crs.