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Abstract the success of allogeneic stem cell transplantation has demonstrated the potential for immunotherapy to treat acute myeloid leukemia (aml) In recent years, with the continuous development of immunotherapy, such as chimeric antigen. For patients battling acute myeloid leukemia (aml), a stem cell transplant can offer a chance of cure However, relapse after transplant remains a major hurdle Now, early results from a phase 1 clinical trial, presented at the 2025 tandem meetings, suggest a novel immunotherapy approach may significantly reduce the risk of aml recurrence after a transplant. Abstract relapse is the leading cause of death after allogeneic hematopoietic stem cell transplantation (hct) for leukemia T cells engineered by gene transfer to express t cell receptors (tcr Hematopoietic stem cell transplantation (hsct) is a particularly important treatment for hematologic malignancies The use of immunotherapy in aml may be most effective when combined with chemotherapy as a bridge to stem cell transplant